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Harebell

Campanula rotundifolia

Names	History	Constituents	Uses
Common Harebell, Campanula rotundifolia, Bluebell Family: Campanulaceae	One of the many ingredients used in homeopathic remedies, the originals are called Bach "Rescue Remedies" Traditional folk use is for pain in ears, also recommended as an ear fungicide for animals in veterinary care. Indigenous to Western Canada	Polyacetylenes: [aliphatic tetrahydropyran derivatives] +, iridoids and tannins 0;caffeic acid.	anti-fungal eye drops for sore eyes ear drops for sore ears anti-depression Potential for Cancer Research? Similar to properties of Campanulaceae family: A Korean called Gymnaster koraiensis yields a polyacetylene in its yellow oil extract which has been observed to: "exhibit potent cytotoxic, antimicrobial, antiviral , RNA-cleaving, sedative, .and enzyme-inhibitory activities, as well as brine-shrimp lethality.* This study finds that the substance is cytotoxic towards some mouse leukemias.

Contra-Indications

from 'local folklore': harebell remedies must be micro-picked for seed potential if used for eye drops, so make your own only if you have the equipment.

Polyacetylenes

 Polyacetylenes have been found in many families of higher plants, such as the Araliaceae, Campanulaceae, Compositae, Olacaceae, Pottosporaceae, Santalaceae, and Umbelliferae.
More recently, linear polyacetylenes have become a major element in the search for bioactive substances from marine sponges.5-7
It has been reported that these compounds exhibit potent cytotoxic, antimicrobial, antiviral, RNA-cleaving, sedative, and enzyme-inhibitory activities, as well as brine-shrimp lethality.
Gymnaster koraiensis (Nakai) Kitamura (Compositae) is an endemic species in Korea, but its constituents and biological activities have not been investigated previously. phytochemistry re: Gymnaster- a sponge which has shown to have some cytotoxicity as its yellow oil extract toward mouse leukemia cells.

http://library.kribb.re.kr

Phytochemistry: References

• campanulaceae ca
  http://www.mobot.org/MOBOT/
  
• Polyacetylenes in tissue cultures of Campanulaceae.
  Recent Research Developments in Phytochemistry (Volume 1): 1-9
  study of Campanulaceae by Ishimaru, K., 1997:   http://homeugs.agri.kagoshima-u.ac.jp
•  clads and Bayesian studies: Campanulacea esp: pp 9-11 http://publications.uu.se/

Cultivation:

studies on prevention of disease in campanula agrobacterium tumefaciens.

A species of gram-negative, aerobic bacteria isolated from soil and the stems and roots of plants.
It causes oncogenic transformations (tumour formation) in a wide variety of higher plants after wounding.
(12 Dec 1998) site : re agrobacterium and bellflower.

http://www.springerlink.com/

Article Plant Cell Reports Publisher:

Springer-Verlag Heidelberg ISSN: 0721-7714 DOI: 10.1007/s002990100341
Issue: Volume 20, Number 4
Date: June 2001
Pages: 289 - 295 Agrobacterium-mediated transformation of Campanula glomerata

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